AKAP13

A-kinase anchor protein 13 ;
AKAP-13 ;
AKAP-Lbc ;
Breast cancer nuclear receptor-binding auxiliary protein ;
Guanine nucleotide exchange factor Lbc ;
Human thyroid-anchoring protein 31 ;
Lymphoid blast crisis oncogene ;
LBC oncogene ;
Non-oncogenic Rho GTPase-specific GTP exchange factor ;
Protein kinase A-anchoring protein 13 ;
PRKA13 ;
p47 ;

caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,domain:Both the DH and PH domains are required for transforming activity.,function:Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element-specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Isoform 6 stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,subunit:Binds cAMP-dependent protein kinase (PKA) and to the RII-alpha regulatory subunit of PKA. Interacts with ESR1, ESR2, THRA, PPARA, RHOA and NME2.,tissue specificity:Isoform 3 and isoform 6 are found in hematopoietic cells, skeletal muscle, lung, heart, estrogen-responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Isoform 6 is not found in brain, placenta, liver, pancreas or kidney. Isoform 7 is expressed in myeloid and lymphoid lineages, a variety of epithelial tissues and skeletal muscle. Isoform 2 is predominantly found in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver.,

apoptosis, induction of apoptosis, intracellular signaling cascade, cell death, induction of apoptosis by extracellular signals, regulation of cell death, positive regulation of cell death, programmed cell death, induction of programmed cell death, death, regulation of Rho protein signal transduction, regulation of apoptosis, positive regulation of apoptosis,regulation of programmed cell death, positive regulation of programmed cell death, regulation of Ras protein signal transduction, regulation of small GTPase mediated signal transduction,

Cytoplasm, cytosol . Cytoplasm . Cytoplasm, cell cortex . Nucleus . Membrane ; Peripheral membrane protein . Colocalizes with the actin cytoskeleton at the cell cortex. .

Detected in mammary gland (PubMed:9627117). Detected in heart (at protein level) (PubMed:11546812). Expressed as a 5.3 kb transcript in hematopoietic cells, skeletal muscle, lung, heart, estrogen-responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Predominantly expressed as a 10 kb transcript in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver. Transcripts of between 6-9 kb are also expressed in myeloid and lymphoid lineages, a variety of epithelial tissues, and in skeletal muscle.