EMX2

Homeobox protein EMX2 ;
Empty spiracles homolog 2 ;
Empty spiracles-like protein 2 ;

disease:Defects in EMX2 are the cause of schizencephaly [MIM:269160]. Schizencephaly is an extremely rare human congenital disorder characterized by a full-thickness cleft within the cerebral hemispheres. These clefts are lined with gray matter and most commonly involve the parasylvian regions. Large portions of the cerebral hemispheres may be absent and replaced by cerebro-spinal fluid.,function:Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.,similarity:Belongs to the EMX homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,tissue specificity:Cerebral cortex.,

regionalization, regulation of transcription, DNA-dependent, cell motion, pattern specification process, cell proliferation,anterior/posterior pattern formation, cell migration, telencephalon development, dentate gyrus development, pallium development, limbic system development, hippocampus development, cerebral cortex regionalization, cell proliferation in forebrain, forebrain regionalization, forebrain cell migration, telencephalon regionalization, cerebral cortex development, neuron differentiation, forebrain development, response to drug, regulation of transcription, cell motility,regulation of RNA metabolic process, localization of cell,

Nucleus .

Cerebral cortex.