RBM5

RNA-binding protein 5 ;
Protein G15 ;
Putative tumor suppressor LUCA15 ;
RNA-binding motif protein 5 ;
Renal carcinoma antigen NY-REN-9 ;

function:Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.,sequence caution:Wrong choice of CDS.,similarity:Belongs to the RBM5/RBM10 family.,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 G-patch domain.,similarity:Contains 1 RanBP2-type zinc finger.,similarity:Contains 2 RRM (RNA recognition motif) domains.,subunit:Component of the spliceosome A complex (also known as the prespliceosome). Appears to dissociate from the spliceosome upon formation of the spliceosome B complex (also known as the precatalytic spliceosome), in which the heterotrimeric U4/U6.U5 snRNPs are bound. Interacts with U2AF2; this interaction is direct. Also interacts with ACIN1, PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200; these interactions may be indirect.,tissue specificity:Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukaemic cell lines.,

spliceosome assembly, RNA splicing, via transesterification reactions, RNA splicing, via transesterification reactions with bulged adenosine as nucleophile, regulation of alternative nuclear mRNA splicing, via spliceosome, nuclear mRNA splicing, via spliceosome, RNA processing, mRNA processing, apoptosis, cell death, negative regulation of cell proliferation, RNA splicing, regulation of cell death, positive regulation of cell death, programmed cell death, mRNA metabolic process, death, ribonucleoprotein complex biogenesis, ribonucleoprotein complex assembly, cellular macromolecular complex subunit organization, cellular macromolecular complex assembly, regulation of cell proliferation, regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, regulation of RNA splicing, macromolecular complex subunit organization,regulation of nuclear mRNA splicing, via spliceosome, regulation of mRNA processing, regulation of RNA metabolic process, macromolecular complex assembly,

Nucleus .

Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines.