MNAT1

CDK-activating kinase assembly factor MAT1 ;
CDK7/cyclin-H assembly factor ;
Cyclin-G1-interacting protein ;
Menage a trois ;
RING finger protein 66 ;
RING finger protein MAT1 ;
p35 ;
p36 ;

function:Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 UIM (ubiquitin-interacting motif) repeat.,subunit:Associates primarily with CDK7 and cyclin H to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.,tissue specificity:Highest levels in colon and testis. Moderate levels are present thymus, prostate, ovary, and small intestine. The lowest levels are found in spleen and leukocytes.,

regulation of cyclin-dependent protein kinase activity, G1/S transition of mitotic cell cycle, mitotic cell cycle, nucleotide-excision repair, DNA damage removal, DNA metabolic process, DNA repair, nucleotide-excision repair, DNA catabolic process, transcription, transcription, DNA-dependent, transcription initiation, RNA elongation, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter, transcription initiation from RNA polymerase II promoter, RNA elongation from RNA polymerase II promoter, protein complex assembly, response to DNA damage stimulus, cell cycle, heart development,adult heart development, cell proliferation, positive regulation of cell proliferation, macromolecule catabolic process,positive regulation of biosynthetic process, response to inorganic substance, response to metal ion, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression, regulation of cell death, regulation of phosphate metabolic process, ventricular system development, cell cycle process, cell cycle phase, positive regulation of cellular biosynthetic process, RNA biosynthetic process, cellular response to stress, regulation of cell proliferation, regulation of phosphorylation, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, regulation of kinase activity, macromolecular complex subunit organization, multicellular organismal metabolic process, cellular macromolecule catabolic process, regulation of transcription, regulation of protein kinase activity, positive regulation of transcription, DNA-dependent, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, regulation of smooth muscle cell proliferation, positive regulation of smooth muscle cell proliferation, positive regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process,regulation of RNA metabolic process, positive regulation of RNA metabolic process, interphase, interphase of mitotic cell cycle, regulation of transferase activity, response to calcium ion, regulation of cell cycle, negative regulation of cell death, macromolecular complex assembly, protein complex biogenesis,

Nucleus.

Highest levels in colon and testis. Moderate levels are present thymus, prostate, ovary, and small intestine. The lowest levels are found in spleen and leukocytes.