GATA4

Transcription factor GATA-4 ;
GATA-binding factor 4 ;

disease:Defects in GATA4 are the cause of atrial septal defect type 2 (ASD2) [MIM:607941]. ASD2 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. ASD2 patients show other heart abnormalities including ventricular and atrioventricular septal defects, pulmonary valve thickening or insufficiency of the cardiac valves. ASD2 is not associated with defects in the cardiac conduction system or non-cardiac abnormalities.,function:Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-5.,similarity:Contains 2 GATA-type zinc fingers.,subunit:Interacts with ZNF260 (By similarity). Interacts with the homeobox domain of NKX2-5 through its C-terminal zinc finger. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with NFATC4.,

in utero embryonic development, gastrulation with mouth forming second, regulation of cytokine production, positive regulation of cytokine production, heart looping, regionalization, heart morphogenesis, transcription, transcription, DNA-dependent, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter, cell-cell signaling, gastrulation, pattern specification process, ectodermal gut development, foregut morphogenesis, heart development, embryonic development ending in birth or egg hatching, positive regulation of biosynthetic process, anterior/posterior pattern formation, positive regulation of macromolecule biosynthetic process, regulation of vascular endothelial growth factor production, positive regulation vascular endothelial growth factor production, positive regulation of macromolecule metabolic process,positive regulation of gene expression, regulation of striated muscle tissue development, positive regulation of cellular biosynthetic process, regulation of gene-specific transcription, RNA biosynthetic process, embryonic heart tube development, embryonic heart tube anterior/posterior pattern formation, tube morphogenesis, tube development,regulation of growth, regulation of cell proliferation, chordate embryonic development, positive regulation of gene-specific transcription, regulation of transcription, regulation of angiogenesis, positive regulation of angiogenesis,positive regulation of transcription, DNA-dependent, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, regulation of organ growth, digestive tract morphogenesis, gut morphogenesis, embryonic digestive tract morphogenesis, embryonic gut morphogenesis, embryonic organ morphogenesis, gut development,embryonic gut development, ectodermal gut morphogenesis, embryonic organ development, embryonic morphogenesis, embryonic foregut morphogenesis, regulation of muscle development, regulation of developmental growth, positive regulation of developmental process, positive regulation of nitrogen compound metabolic process,positive regulation of multicellular organismal process, regulation of RNA metabolic process, positive regulation of RNA metabolic process, regulation of cardiac muscle growth, regulation of cardiac muscle tissue development, digestive system development, regulation of cardiac muscle cell proliferation, regulation of heart growth,

Nucleus .