ACVR1B

Activin receptor type-1B ;
Activin receptor type IB ;
ACTR-IB ;
Activin receptor-like kinase 4 ;
ALK-4 ;
Serine/threonine-protein kinase receptor R2 ;
SKR2 ;

catalytic activity:ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.,cofactor:Magnesium or manganese.,function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Phosphorylates TTRAP.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.,similarity:Contains 1 GS domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3. Interacts with TTRAP.,tissue specificity:Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.,

G1/S transition of mitotic cell cycle, mitotic cell cycle, regulation of cell growth, in utero embryonic development, hair follicle development, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, induction of apoptosis, cell cycle, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein serine/threonine kinase signaling pathway, ectoderm development, regulation of cell size, epidermis development, embryonic development ending in birth or egg hatching,positive regulation of signal transduction, positive regulation of cell communication, regulation of cell death, positive regulation of cell death, induction of programmed cell death, phosphorylation, peptidyl-threonine phosphorylation,peptidyl-threonine modification, cell cycle process, cell cycle phase, molting cycle process, hair cycle process, negative regulation of cell growth, regulation of cellular component size, regulation of homeostatic process, regulation of activin receptor signaling pathway, positive regulation of activin receptor signaling pathway, regulation of growth, molting cycle, hair cycle, regulation of apoptosis, chordate embryonic development, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, regulation of transcription, positive regulation of cell differentiation, regulation of myeloid cell differentiation, positive regulation of myeloid cell differentiation,regulation of erythrocyte differentiation, positive regulation of erythrocyte differentiation, negative regulation of cell size, negative regulation of growth, protein amino acid autophosphorylation, positive regulation of developmental process, interphase, interphase of mitotic cell cycle,

Cell membrane ; Single-pass type I membrane protein .

Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.