EPHB2

Ephrin type-B receptor 2 ;
Developmentally-regulated Eph-related tyrosine kinase ;
ELK-related tyrosine kinase ;
EPH tyrosine kinase 3 ;
EPH-like kinase 5 ;
EK5 ;
hEK5 ;
Renal carcinoma antigen NY-REN-47 ;
Tyrosine-protein kinase TYRO5 ;
Tyrosine-protein kinase receptor EPH-3 ;

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in EPHB2 are involved in the development of prostate cancer metastasis to the brain [MIM:603688].,disease:Defects in EPHB2 are involved in the progression of prostate cancer [MIM:176807].,function:Receptor for members of the ephrin-B family. Acts as a tumor suppressor.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:The ligand-activated form interacts with multiple proteins, including GTPase-activating protein (RASGAP) through its SH2 domain. Binds RASGAP through the juxtamembrane tyrosines residues. Interacts with PRKCABP and GRIP1.,tissue specificity:Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.,

cell morphogenesis, cell morphogenesis involved in differentiation, eye development, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cell motion, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, axonogenesis, axon guidance, sensory organ development, behavior, learning or memory,learning, positive regulation of cell development, negative regulation of cell development, regulation of cell morphogenesis involved in differentiation, regulation of neuron projection development, phosphorylation, peptidyl-tyrosine phosphorylation, peptidyl-tyrosine modification, cranial nerve development, optic nerve development, cranial nerve morphogenesis, optic nerve morphogenesis, nerve development, central nervous system projection neuron axonogenesis, central nervous system neuron differentiation, central nervous system neuron development, central nervous system neuron axonogenesis, regulation of cell morphogenesis, cell projection organization, neuron differentiation, neuron projection development, retinal ganglion cell axon guidance, regulation of cell projection organization, negative regulation of cell projection organization, regulation of neurological system process, cellular component morphogenesis, cell part morphogenesis, camera-type eye development, regulation of system process,negative regulation of cell differentiation, positive regulation of cell differentiation, regulation of neuron differentiation,ephrin receptor signaling pathway, regulation of synaptic plasticity, regulation of neuronal synaptic plasticity,regulation of long-term neuronal synaptic plasticity, positive regulation of long-term neuronal synaptic plasticity, eye morphogenesis, camera-type eye morphogenesis, neuron development, cell morphogenesis involved in neuron differentiation, neuron projection morphogenesis, cell projection morphogenesis, regulation of neurogenesis, negative regulation of neurogenesis, positive regulation of neurogenesis, regulation of axonogenesis, negative regulation of axonogenesis, regulation of synaptic transmission, neurological system process, cognition, positive regulation of developmental process, negative regulation of cellular component organization, regulation of nervous system development, regulation of transmission of nerve impulse, regulation of cell development,

Cell membrane; Single-pass type I membrane protein. Cell projection, axon . Cell projection, dendrite .

Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.