ARNT

Aryl hydrocarbon receptor nuclear translocator ;
ARNT protein ;
Class E basic helix-loop-helix protein 2 ;
bHLHe2 ;
Dioxin receptor, nuclear translocator ;
Hypoxia-inducible factor 1-beta ;
HIF-1-beta ;
HIF1-beta ;

function:Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 2 PAS (PER-ARNT-SIM) domains.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with AHR, AHRR, HIF1A and EPAS1/HIF2A as well as with other bHLH proteins. Interacts with TACC3 (By similarity). Interacts with NOCA7.,

response to hypoxia, in utero embryonic development, regulation of cytokine production, positive regulation of cytokine production, placenta development, embryonic placenta development, regulation of endothelial cell proliferation, positive regulation of endothelial cell proliferation, regulation of carbohydrate metabolic process,regulation of glycolysis, transcription, transcription, DNA-dependent, regulation of transcription, DNA-dependent,regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter, response to oxidative stress, positive regulation of cell proliferation, mRNA transcription, embryonic development ending in birth or egg hatching, positive regulation of biosynthetic process, regulation of catabolic process, positive regulation of catabolic process, positive regulation of signal transduction, positive regulation of macromolecule biosynthetic process,regulation of vascular endothelial growth factor production, positive regulation vascular endothelial growth factor production, positive regulation of macromolecule metabolic process, positive regulation of gene expression, positive regulation of cell communication, regulation of cellular carbohydrate metabolic process, positive regulation of cellular carbohydrate metabolic process, regulation of glucose metabolic process, positive regulation of glucose metabolic process, regulation of vascular endothelial growth factor receptor signaling pathway, positive regulation of vascular endothelial growth factor receptor signaling pathway, positive regulation of cellular biosynthetic process, regulation of cellular catabolic process, positive regulation of cellular catabolic process, regulation of hormone metabolic process,positive regulation of hormone metabolic process, regulation of gene-specific transcription, RNA biosynthetic process,regulation of homeostatic process, cellular response to stress, cellular response to oxidative stress, regulation of cell proliferation, mRNA transcription from RNA polymerase II promoter, chordate embryonic development, positive regulation of gene-specific transcription, regulation of generation of precursor metabolites and energy, regulation of carbohydrate catabolic process, regulation of cellular carbohydrate catabolic process, regulation of transcription from RNA polymerase II promoter in response to stress, regulation of transcription from RNA polymerase II promoter in response to oxidative stress, regulation of transcription in response to stress, regulation of transcription, positive regulation of cell differentiation, regulation of myeloid cell differentiation, positive regulation of myeloid cell differentiation, regulation of erythrocyte differentiation, positive regulation of erythrocyte differentiation, positive regulation of glycolysis, positive regulation of transcription, DNA-dependent, positive regulation of carbohydrate metabolic process, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process,positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, regulation of hormone biosynthetic process, positive regulation of hormone biosynthetic process, embryonic organ development,positive regulation of developmental process, positive regulation of nitrogen compound metabolic process, positive regulation of multicellular organismal process, regulation of RNA metabolic process, positive regulation of RNA metabolic process, response to oxygen levels,

Nucleus.