AKAP5

A-kinase anchor protein 5 ;
AKAP-5 ;
A-kinase anchor protein 79 kDa ;
AKAP 79 ;
H21 ;
cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein ;

domain:RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.,function:May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade.,miscellaneous:The N-terminal region, which is highly basic, is required for interaction with calmodulin.,similarity:Contains 1 AKAP domain.,subcellular location:Associated with particulate fractions.,subunit:Binding protein for dimer of the RII-beta regulatory subunit of cAMP-dependent protein kinase (PKA) and also for the protein kinase C (PKC) and the phosphatase calcineurin (PP2B). Each enzyme is inhibited when bound to the anchoring protein. Also binds the beta2-adrenergic receptor.,tissue specificity:Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary.,

protein targeting, intracellular protein transport, cell-cell signaling, synaptic transmission, protein localization, protein transport, transmission of nerve impulse, regulation of organelle organization, cellular protein localization,establishment of protein localization, intracellular transport, neurological system process, regulation of cytoskeleton organization, cellular macromolecule localization,

Postsynaptic recycling endosome membrane ; Lipid-anchor . Associates with lipid rafts. .

Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary.