TAF1

Transcription initiation factor TFIID subunit 1 ;
Cell cycle gene 1 protein ;
TBP-associated factor 250 kDa ;
p250 ;
Transcription initiation factor TFIID 250 kDa subunit ;
TAF ;
II ;
250 ;
TAFII-250 ;
TAFII250 ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,disease:Defects in TAF1 are the cause of dystonia type 3 (DYT3) [MIM:314250]; also called X-linked dystonia-parkinsonism (XDP). DYT3 is a X-linked dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT3 is characterized by severe progressive torsion dystonia followed by parkinsonism. Its prevalence is high in the Philippines. DYT3 has a well-defined pathology of extensive neuronal loss and mosaic gliosis in the striatum (caudate nucleus and putamen) which appears to resemble that in Huntington disease.,enzyme regulation:Autophosphorylates on Ser residues. Inhibited by retinoblastoma tumor suppressor protein, RB1.,function:Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle.,PTM:Phosphorylated by casein kinase II in vitro.,similarity:Belongs to the TAF1 family.,similarity:Contains 1 HMG box DNA-binding domain.,similarity:Contains 2 bromo domains.,similarity:Contains 2 protein kinase domains.,subunit:TAF1 is the largest component of transcription factor TFIID that is composed of TBP and a variety of TBP-associated factors. TAF1, when part of the TFIID complex, interacts with C-terminus of TP53. RB1 interacts with the N-terminal domain of TAF1. Interacts with ASF1A and ASF1B. Interacts with SV40 Large T antigen.,

G1 phase of mitotic cell cycle, G2/M transition of mitotic cell cycle, regulation of transcription during G2/M-phase of mitotic cell cycle, mitotic cell cycle, transcription, transcription, DNA-dependent, transcription initiation, RNA elongation,regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter, transcription initiation from RNA polymerase II promoter, RNA elongation from RNA polymerase II promoter, protein complex assembly, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cell cycle, positive regulation of biosynthetic process, regulation of catabolic process, positive regulation of catabolic process, regulation of specific transcription from RNA polymerase II promoter,positive regulation of specific transcription from RNA polymerase II promoter, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression,phosphorylation, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, peptidyl-serine modification,peptidyl-threonine modification, cell cycle process, cell cycle phase, regulation of proteolysis, positive regulation of cellular biosynthetic process, regulation of cellular catabolic process, positive regulation of cellular catabolic process,positive regulation of protein complex assembly, regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, regulation of gene-specific transcription, RNA biosynthetic process, cellular macromolecular complex subunit organization, cellular macromolecular complex assembly,cellular response to DNA damage stimulus, regulation of protein catabolic process, positive regulation of gene-specific transcription, regulation of protein complex assembly, macromolecular complex subunit organization, regulation of cellular component biogenesis, regulation of transcription, positive regulation of protein catabolic process, positive regulation of proteolysis, positive regulation of transcription, DNA-dependent, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, protein amino acid autophosphorylation, transcriptional preinitiation complex assembly, positive regulation of cellular component organization, positive regulation of nitrogen compound metabolic process, positive regulation of protein metabolic process, regulation of RNA metabolic process, positive regulation of RNA metabolic process, G1 phase, interphase, interphase of mitotic cell cycle, regulation of transcription initiation from RNA polymerase II promoter, positive regulation of transcription initiation from RNA polymerase II promoter, macromolecular complex assembly, protein-DNA complex assembly, protein complex biogenesis,

Nucleus .