EFNA1

Ephrin-A1 ;
EPH-related receptor tyrosine kinase ligand 1 ;
LERK-1 ;
Immediate early response protein B61 ;
Tumor necrosis factor alpha-induced protein 4 ;
TNF alpha-induced protein 4 ;
[Cleaved into: Ephrin-A1, secreted form]

induction:By TNF-alpha and interleukin-1 beta.,similarity:Belongs to the ephrin family.,subunit:Binds to the receptor tyrosine kinases EPHA2, EPHA4, EPHA5, EPHA6 and EPHA7. Also binds with low affinity to EPHA1.,

MAPKKK cascade, activation of MAPK activity, protein amino acid phosphorylation, phosphorus metabolic process,phosphate metabolic process, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, intracellular signaling cascade,protein kinase cascade, cell-cell signaling, regulation of cell morphogenesis involved in differentiation, regulation of neuron projection development, phosphorylation, regulation of phosphate metabolic process, regulation of cell morphogenesis, neuron differentiation, regulation of cell projection organization, positive regulation of kinase activity,regulation of phosphorylation, positive regulation of catalytic activity, regulation of MAP kinase activity, positive regulation of MAP kinase activity, regulation of kinase activity, positive regulation of molecular function, regulation of neuron differentiation, regulation of protein kinase activity, positive regulation of protein kinase activity, ephrin receptor signaling pathway, regulation of neurogenesis, regulation of axonogenesis, regulation of phosphorus metabolic process, regulation of transferase activity, positive regulation of transferase activity, regulation of nervous system development, regulation of cell development,

Cell membrane ; Lipid-anchor, GPI-anchor .; [Ephrin-A1, secreted form]: Secreted .

Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level).