TNFRSF1B

Tumor necrosis factor receptor superfamily member 1B ;
Tumor necrosis factor receptor 2 ;
TNF-R2 ;
Tumor necrosis factor receptor type II ;
TNF-RII ;
TNFR-II ;
p75 ;
p80 TNF-alpha receptor ;
CD antigen CD120b ;
Etanercept ;
[Cleaved into: Tumor necrosis factor receptor superfamily member 1b, membrane form ;
Tumor necrosis factor-binding protein 2 ;
TBP-2 ;
TBPII ;
]

function:Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.,online information:Clinical information on Enbrel,pharmaceutical:Available under the name Enbrel (Immunex and Wyeth-Ayerst). Used to treat moderate to severe rheumatoid arthritis (RA). Enbrel consist of the extracellular ligand-binding portion of TNFRSF1B linked to an immunoglobulin Fc chain. It binds to TNF-alpha and blocks its interactions with receptors.,PTM:A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.,PTM:Phosphorylated; mainly on serine residues and with a very low level on threonine residues.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Binds to TRAF2.,

apoptosis, defense response, inflammatory response, immune response, cell surface receptor linked signal transduction, cell death, response to wounding, posttranscriptional regulation of gene expression, programmed cell death, death, negative regulation of defense response, regulation of response to external stimulus, negative regulation of response to external stimulus, regulation of RNA stability, negative regulation of response to stimulus,regulation of inflammatory response, negative regulation of inflammatory response, RNA destabilization, regulation of RNA metabolic process,

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Tumor necrosis factor-binding protein 2]: Secreted.