ADRA2B

Alpha-2B adrenergic receptor ;
Alpha-2 adrenergic receptor subtype C2 ;
Alpha-2B adrenoreceptor ;
Alpha-2B adrenoceptor ;
Alpha-2BAR ;

function:Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.,polymorphism:A rare polymorphic framshift in position 451 produces a protein of 542 residues.,similarity:Belongs to the G-protein coupled receptor 1 family.,

MAPKKK cascade, activation of MAPK activity, angiogenesis, blood vessel development, vasculature development,protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway, intracellular signaling cascade, protein kinase cascade, cell-cell signaling, phosphorylation, regulation of phosphate metabolic process,positive regulation of kinase activity, regulation of phosphorylation, positive regulation of catalytic activity, regulation of MAP kinase activity, positive regulation of MAP kinase activity, regulation of kinase activity, positive regulation of molecular function, regulation of protein kinase activity, positive regulation of protein kinase activity, blood vessel morphogenesis, regulation of phosphorus metabolic process, regulation of transferase activity, positive regulation of transferase activity,

Cell membrane ; Multi-pass membrane protein . Interaction with RAB26, GGA1, GGA2 and GGA3 mediates transport from the Golgi to the cell membrane. .