Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

FIGF

Vascular endothelial growth factor D

FIGF ;
VEGFD ;
Vascular endothelial growth factor D ;
VEGF-D ;
c-Fos-induced growth factor ;
FIGF

function:Growth factor active in angiogenesis , lymphangiogenesis and endothelial cell growth , stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis , and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (Flk1) and VEGFR-3 (Flt4) receptors. ,PTM:Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions. ,similarity:Belongs to the PDGF/VEGF growth factor family. ,subunit:Homodimer; non-covalent and antiparallel. ,tissue specificity:Highly expressed in lung , heart , small intestine and fetal lung , and at lower levels in skeletal muscle , colon , and pancreas. ,

angiogenesis , blood vessel development , vasculature development , cell surface receptor linked signal transduction ,enzyme linked receptor protein signaling pathway , transmembrane receptor protein tyrosine kinase signaling pathway , cell proliferation , positive regulation of cell proliferation , regulation of cell proliferation , vascular endothelial growth factor receptor signaling pathway , blood vessel morphogenesis , regulation of cell division , positive regulation of cell division ,

Secreted.