Total DNA pol α Cell-Based Colorimetric ELISA Kit
-KA3532C
主要信息
Reactivity
Human
Applications
ELISA
Conjugate/Modification
Unmodified
详细信息
储存
2-8°C/6 months
修饰
Unmodified
检测方法
Colorimetric
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抗原&靶点信息
基因名称:
POLA1
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别名:
DNA polymerase alpha catalytic subunit ;
DNA polymerase alpha catalytic subunit p180 ;
DNA polymerase alpha catalytic subunit p180 ;
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背景:
catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,function:Polymerase alpha in a complex with DNA primase is a replicative polymerase.,miscellaneous:In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.,PTM:A 165 kDa form is probably produced by proteolytic cleavage at Lys-124.,similarity:Belongs to the DNA polymerase type-B family.,subunit:Interacts with SV40 Large T antigen; this interaction allows viral DNA replication.,
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功能:
S phase of mitotic cell cycle, mitotic cell cycle, non-recombinational repair, DNA synthesis during DNA repair, DNA metabolic process, DNA replication, DNA-dependent DNA replication, DNA replication initiation, DNA strand elongation during DNA replication, leading strand elongation, lagging strand elongation, DNA repair, double-strand break repair,double-strand break repair via nonhomologous end joining, response to DNA damage stimulus, cell cycle, cell proliferation, cell cycle process, cell cycle phase, DNA strand elongation, cellular response to stress, S phase,interphase, interphase of mitotic cell cycle,
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细胞定位:
Nucleus . Cytoplasm, cytosol . In the cytosol, colocalizes with RNA:DNA hybrids with a speckled pattern. .
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