disease:Genetic variations in THBS2 may be a cause of susceptibility to lumbar disk herniation (LDH) [MIM:603932]. LDH is the predominant cause of low-back pain and unilateral leg pain. ,function:Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen , fibronectin , laminin and type V collagen. ,similarity:Belongs to the thrombospondin family. ,similarity:Contains 1 TSP C-terminal (TSPC) domain. ,similarity:Contains 1 TSP N-terminal (TSPN) domain. ,similarity:Contains 1 VWFC domain. ,similarity:Contains 3 EGF-like domains. ,similarity:Contains 3 TSP type-1 domains. ,similarity:Contains 8 TSP type-3 repeats. ,subunit:Homotrimer; disulfide-linked. ,tissue specificity:High expression in invertebral disk tissue. ,
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