domain:This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF , the second one with Xa. ,function:Inhibits factor X (X (a) ) directly and , in a Xa-dependent way , inhibits VIIa/tissue factor activity , presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. ,online information:TFPI entry ,PTM:O-glycosylated. ,similarity:Contains 2 BPTI/Kunitz inhibitor domains. ,similarity:Contains 3 BPTI/Kunitz inhibitor domains. ,tissue specificity:Mostly in endothelial cells. ,
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