MBD3

Methyl-CpG-binding domain protein 3 ;
Methyl-CpG-binding protein MBD3 ;

function:Does not bind DNA by itself. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing.,similarity:Contains 1 MBD (methyl-CpG-binding) domain.,subcellular location:Nuclear, in discrete foci.,subunit:Heterodimer with MBD2. Part of the NuRD and the MeCP1 complex. Binds HDAC1, MTA2, DNMT1, p66-alpha and p66-beta.,

negative regulation of transcription from RNA polymerase II promoter, in utero embryonic development, chromatin organization, chromatin silencing, methylation-dependent chromatin silencing, transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein amino acid acetylation, embryonic development ending in birth or egg hatching, negative regulation of biosynthetic process,negative regulation of macromolecule biosynthetic process, negative regulation of macromolecule metabolic process,negative regulation of gene expression, gene silencing, negative regulation of transcription, chromatin modification,covalent chromatin modification, histone modification, histone acetylation, negative regulation of cellular biosynthetic process, regulation of gene expression, epigenetic, chordate embryonic development, protein amino acid acylation,regulation of transcription, negative regulation of gene expression, epigenetic, negative regulation of transcription, DNA-dependent, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process,negative regulation of nitrogen compound metabolic process, regulation of RNA metabolic process, negative regulation of RNA metabolic process, chromosome organization,

Nucleus. Chromosome. Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes.