Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

PDGFA/PDGFB

Platelet-derived growth factor subunit A/Platelet-derived growth factor subunit B

PDGFA ;
PDGF1 ;
Platelet-derived growth factor subunit A ;
PDGF subunit A ;
PDGF-1 ;
Platelet-derived growth factor A chain ;
Platelet-derived growth factor alpha polypeptide ;
PDGFB ;
PDGF2 ;
SIS ;
Platelet-derived growth factor subunit B ;
PDGF subu

domain:The long form contains a basic insert which acts as a cell retention signal. ,function:Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound. ,miscellaneous:A-A and B-B , as well as A-B , dimers can bind to the PDGF receptor. ,similarity:Belongs to the PDGF/VEGF growth factor family. ,subunit:Antiparallel disulfide-linked dimer of non-identical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes. Interacts with CSPG4. ,

angiogenesis , blood vessel development , response to hypoxia , cell activation , regulation of protein amino acid phosphorylation , hair follicle development , vasculature development , positive regulation of mesenchymal cell proliferation , regulation of DNA replication , chemotaxis , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein tyrosine kinase signaling pathway ,transmembrane receptor protein serine/threonine kinase signaling pathway , transforming growth factor beta receptor signaling pathway , cell-cell signaling , ectoderm development , sensory organ development , response to nutrient ,behavior , locomotory behavior , cell proliferation , positive regulation of cell proliferation , epidermis development ,response to wounding , response to endogenous stimulus , response to hormone stimulus , negative regulation of biosynthetic process , positive regulation of biosynthetic process , response to extracellular stimulus , response to organic substance , response to inorganic substance , regulation of mesenchymal cell proliferation , regulation of phosphatidylinositol biosynthetic process , negative regulation of phosphatidylinositol biosynthetic process , regulation of platelet activation , negative regulation of platelet activation , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , regulation of smooth muscle cell migration ,regulation of lipid metabolic process , regulation of phosphate metabolic process , molting cycle process , hair cycle process , cell projection organization , cell projection assembly , regulation of blood coagulation , negative regulation of blood coagulation , respiratory tube development , lung development , regulation of cell migration , positive regulation of cell migration , negative regulation of cellular biosynthetic process , positive regulation of cellular biosynthetic process ,regulation of protein modification process , response to nutrient levels , regulation of response to external stimulus ,regulation of cellular protein metabolic process , response to estradiol stimulus , response to retinoic acid , regulation of actin cytoskeleton organization , regulation of actin filament-based process , regulation of organelle organization ,response to vitamin A , response to vitamin , tube development , regulation of locomotion , positive regulation of locomotion , wound healing , regulation of cell proliferation , molting cycle , regulation of phosphorylation , taxis , response to drug , hair cycle , ear development , skin development , response to estrogen stimulus , positive regulation of DNA replication , negative regulation of lipid metabolic process , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , regulation of lipid biosynthetic process , platelet-derived growth factor receptor signaling pathway , regulation of fibroblast proliferation , positive regulation of fibroblast proliferation , lung alveolus development , blood vessel morphogenesis , response to steroid hormone stimulus , inner ear development , regulation of peptidyl-tyrosine phosphorylation , regulation of coagulation , negative regulation of coagulation , regulation of cell activation , negative regulation of cell activation , negative chemotaxis , regulation of DNA metabolic process , positive regulation of DNA metabolic process , negative regulation of lipid biosynthetic process , positive regulation of nitrogen compound metabolic process , regulation of phosphorus metabolic process , negative regulation of multicellular organismal process , regulation of cell motion , positive regulation of cell motion , regulation of cell division , regulation of cytoskeleton organization , positive regulation of cell division , respiratory system development , response to oxygen levels ,

Secreted. Released by platelets upon wounding.