YEATS4

YEATS domain-containing protein 4 ;
Glioma-amplified sequence 41 ;
Gas41 ;
NuMA-binding protein 1 ;
NuBI-1 ;
NuBI1 ;

function:Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.,similarity:Contains 1 YEATS domain.,subunit:Component of numerous complexes with chromatin remodeling and histone acetyltransferase activity. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit HTATIP/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and EAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. YEATS4 interacts with MLLT10/AF10. YEATS4 may also interact with the SWI/SNF component SMARCB1/BAF47, TACC1 and TACC2, and the nuclear matrix protein NUMA1.,tissue specificity:Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.,

M phase of mitotic cell cycle, mitotic cell cycle, M phase, nuclear division, chromatin organization, transcription,regulation of transcription, DNA-dependent, protein amino acid acetylation, cell cycle, mitosis, positive regulation of biosynthetic process, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression, chromatin modification, covalent chromatin modification,histone modification, histone acetylation, cell cycle process, cell cycle phase, positive regulation of cellular biosynthetic process, regulation of growth, protein amino acid acylation, histone H4 acetylation, histone H2A acetylation, regulation of transcription, positive regulation of transcription, DNA-dependent, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, organelle fission, positive regulation of nitrogen compound metabolic process, regulation of RNA metabolic process, positive regulation of RNA metabolic process, chromosome organization,

Nucleus .

Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.