Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

MIF

Macrophage migration inhibitory factor

MIF ;
GLIF ;
MMIF ;
Macrophage migration inhibitory factor ;
MIF ;
Glycosylation-inhibiting factor ;
GIF ;
L-dopachrome isomerase ;
L-dopachrome tautomerase ;
Phenylpyruvate tautomerase

catalytic activity:Keto-phenylpyruvate = enol-phenylpyruvate. ,disease:Genetic variations in MIF are associated with susceptibility to systemic juvenile rheumatoid arthritis [MIM:604302]. Systemic juvenile rheumatoid arthritis is juvenile chronic arthritis associated with severe , debilitating , extraarticular features , and occasionally fatal complications. Despite medical treatment , many children still experience early joint destruction , necessitating surgical replacement. ,function:The expression of MIF at sites of inflammation suggest a role for the mediator in regulating the function of macrophage in host defense. Also acts as a phenylpyruvate tautomerase. ,similarity:Belongs to the MIF family. ,subunit:Homotrimer. Interacts with COPS5 and BNIPL. ,

prostaglandin biosynthetic process , regulation of leukocyte activation , protein complex assembly , fatty acid metabolic process , fatty acid biosynthetic process , unsaturated fatty acid biosynthetic process , icosanoid metabolic process ,prostanoid metabolic process , prostaglandin metabolic process , defense response , inflammatory response , immune response , cell surface receptor linked signal transduction , cell proliferation , lipid biosynthetic process , response to wounding , regulation of cell death , organic acid biosynthetic process , unsaturated fatty acid metabolic process ,regulation of apoptosis , regulation of macrophage activation , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death , macromolecular complex subunit organization ,innate immune response , carboxylic acid biosynthetic process , icosanoid biosynthetic process , prostanoid biosynthetic process , regulation of cell activation , protein oligomerization , protein homooligomerization , negative regulation of cell death , macromolecular complex assembly , protein trimerization , protein homotrimerization , protein complex biogenesis ,

Secreted . Cytoplasm . Does not have a cleavable signal sequence and is secreted via a specialized , non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS) , or by M.tuberculosis antigens. .