disease:Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. ,function:Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro. ,function:Membrane-anchored forms may play a role in cellular adhesion. ,PTM:Both MPF and the cleaved form of mesothelin are N-glycosylated. ,PTM:Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF) , and the cleaved form of mesothelin. ,similarity:Belongs to the mesothelin family. ,subunit:Interacts with MUC16. ,tissue specificity:Expressed in lung. Expressed at low levels in heart , placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas , ovarian cancers , and some squamous cell carcinomas (at protein level) . ,
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