MED26

Mediator of RNA polymerase II transcription subunit 26 ;
Activator-recruited cofactor 70 kDa component ;
ARC70 ;
Cofactor required for Sp1 transcriptional activation subunit 7 ;
CRSP complex subunit 7 ;
Mediator complex subunit 26 ;
Transcriptional coactivator CRSP70 ;

function:Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.,similarity:Belongs to the Mediator complex subunit 26 family.,similarity:Contains 1 TFIIS N-terminal domain.,subunit:Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.,

transcription, transcription, DNA-dependent, transcription initiation, regulation of transcription, DNA-dependent,regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter,transcription initiation from RNA polymerase II promoter, protein complex assembly, RNA biosynthetic process,macromolecular complex subunit organization, regulation of transcription, regulation of RNA metabolic process,macromolecular complex assembly, protein complex biogenesis,

Nucleus .