Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

TNFSF14

Tumor necrosis factor ligand superfamily member 14

TNFSF14 ;
HVEML ;
LIGHT ;
Tumor necrosis factor ligand superfamily member 14 ;
Herpes virus entry mediator ligand ;
HVEM-L ;
Herpesvirus entry mediator ligand ;
CD antigen CD258

function:Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB , stimulates the proliferation of T-cells , and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus. ,induction:Up-regulated after T-cell activation. ,PTM:N-glycosylated. ,PTM:The soluble form of isoform 1 derives from the membrane form by proteolytic processing. ,similarity:Belongs to the tumor necrosis factor family. ,subunit:Homotrimer. ,tissue specificity:Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart , placenta , liver , lung , appendix , and kidney , and no expression seen in fetal tissues , endocrine glands , or nonhematopoietic tumor lines. ,

cell activation , leukocyte homeostasis , lymphocyte homeostasis , positive regulation of immune system process ,regulation of leukocyte activation , positive regulation of leukocyte activation , induction of apoptosis , immune response , intracellular signaling cascade , protein kinase cascade , I-kappaB kinase/NF-kappaB cascade , cell proliferation , release of cytoplasmic sequestered NF-kappaB , regulation of cell death , positive regulation of cell death ,induction of programmed cell death , lymphocyte costimulation , T cell costimulation , regulation of intracellular transport ,positive regulation of intracellular transport , regulation of protein localization , mononuclear cell proliferation ,regulation of intracellular protein transport , T cell proliferation , T cell activation , regulation of protein import into nucleus , positive regulation of protein import into nucleus , regulation of NF-kappaB import into nucleus , positive regulation of NF-kappaB import into nucleus , homeostatic process , regulation of apoptosis , regulation of transcription factor import into nucleus , positive regulation of transcription factor import into nucleus , T cell homeostasis , positive regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , leukocyte activation , lymphocyte activation , lymphocyte proliferation , regulation of nucleocytoplasmic transport , positive regulation of nucleocytoplasmic transport , homeostasis of number of cells , regulation of T cell activation , regulation of cell activation , positive regulation of cell activation , positive regulation of T cell activation , positive regulation of transport , positive regulation of protein transport , regulation of protein transport , regulation of lymphocyte activation ,positive regulation of lymphocyte activation , regulation of cellular localization , regulation of establishment of protein localization , leukocyte proliferation ,

[Tumor necrosis factor ligand superfamily member 14 , membrane form]: Cell membrane; Single-pass type II membrane protein.; [Tumor necrosis factor ligand superfamily member 14 , soluble form]: Secreted.; [Isoform 2]: Cytoplasm.