function:Ligand for tyrosine-protein kinase receptors AXL , TYRO3 and MER whose signaling is implicated in cell growth and survival , cell adhesion and cell migration. Plays a role in thrombosis by amplifying platelet aggregation and secretion in response to known agonists. ,PTM:Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium. ,PTM:Isoform 1 is proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL. ,similarity:Contains 1 Gla (gamma-carboxy-glutamate) domain. ,similarity:Contains 2 laminin G-like domains. ,similarity:Contains 4 EGF-like domains. ,subunit:Heterodimer and heterotetramer with AXL. ,tissue specificity:Plasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the predominant form in spleen. ,
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