TNFSF15

Tumor necrosis factor ligand superfamily member 15 ;
TNF ligand-related molecule 1 ;
Vascular endothelial cell growth inhibitor ;
[Cleaved into: Tumor necrosis factor ligand superfamily member 15, membrane form ;
Tumor necrosis factor ligand superfamily member 15, secreted form]

function:Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.,induction:Up-regulated by IL-1-alpha and TNF-alpha.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer.,tissue specificity:Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.,

regulation of cytokine production, regulation of endothelial cell proliferation, negative regulation of endothelial cell proliferation, apoptosis, activation of caspase activity, immune response, intracellular signaling cascade, protein kinase cascade, I-kappaB kinase/NF-kappaB cascade, activation of NF-kappaB-inducing kinase activity, cell death,negative regulation of cell proliferation, regulation of cell death, positive regulation of peptidase activity, programmed cell death, death, regulation of phosphate metabolic process, activation of protein kinase activity, regulation of protein localization, positive regulation of kinase activity, cytokine metabolic process, regulation of cell proliferation, regulation of phosphorylation, regulation of apoptosis, regulation of programmed cell death, positive regulation of catalytic activity, positive regulation of caspase activity, regulation of caspase activity, regulation of kinase activity, positive regulation of molecular function, regulation of protein kinase activity, positive regulation of protein kinase activity,regulation of cytokine secretion, regulation of protein secretion, positive regulation of protein secretion, positive regulation of cytokine secretion, regulation of secretion, positive regulation of secretion, positive regulation of transport, regulation of phosphorus metabolic process, positive regulation of protein transport, regulation of protein transport, regulation of hydrolase activity, regulation of transferase activity, positive regulation of hydrolase activity,positive regulation of transferase activity, regulation of peptidase activity, regulation of endopeptidase activity,regulation of cellular localization, regulation of establishment of protein localization,

Membrane ; Single-pass type II membrane protein .; [Tumor necrosis factor ligand superfamily member 15, secreted form]: Secreted.

Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.