Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

DPP4 ADCP2 CD26

Dipeptidyl peptidase 4 (ADABP) (Adenosine deaminase complexing protein 2) (ADCP-2) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form) ; Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form) ]

DPP4 ;
ADCP2 ;
CD26 ;
Dipeptidyl peptidase 4 ;
ADABP ;
Adenosine deaminase complexing protein 2 ;
ADCP-2 ;
Dipeptidyl peptidase IV ;
DPP IV ;
T-cell activation antigen CD26 ;
TP103 ;
CD26 ;
CD26 nanobody ;

catalytic activity:Release of an N-terminal dipeptide , Xaa-Yaa-|-Zaa- , from a polypeptide , preferentially when Yaa is Pro , provided Zaa is neither Pro nor hydroxyproline. ,function:Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Plays a role in T-cell activation. ,online information:Dipeptidyl peptidase-4 entry ,PTM:The soluble form (SDPP) derives from the membrane form (MDPP) by proteolytic processing. ,similarity:Belongs to the peptidase S9B family. DPPIV subfamily. ,subunit:Homodimer or heterodimer with Seprase (FAP) . ,tissue specificity:Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon. ,

response to hypoxia , cell activation , regulation of immune effector process , regulation of leukocyte mediated immunity ,regulation of lymphocyte mediated immunity , regulation of T cell mediated immunity , regulation of adaptive immune response , regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains , proteolysis , regulation of cell-cell adhesion , regulation of cell adhesion ,regulation of cell adhesion mediated by integrin , regulation of cell-cell adhesion mediated by integrin , T cell activation ,leukocyte activation , lymphocyte activation , response to oxygen levels ,

[Dipeptidyl peptidase 4 soluble form]: Secreted . Detected in the serum and the seminal fluid. .; Cell membrane ; Single-pass type II membrane protein. Apical cell membrane ; Single-pass type II membrane protein. Cell projection , invadopodium membrane ; Single-pass type II membrane protein. Cell projection , lamellipodium membrane ; Single-pass type II membrane protein. Cell junction . Membrane raft . Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids (PubMed:11773049) . Redistributed to membrane rafts in T-cell in an interleukin-12-dependent activation (PubMed:12676959) . Its interaction with CAV1 is necessary for its translocation to membrane rafts (PubMed:17287217) . Colocalized with PTPRC in membrane rafts (PubMed:12676959) . Colocalized with FAP in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with FAP on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma (PubMed:16651416) . Colocalized with ADA at the cell junction in lymphocyte-epithelial cell adhesion (PubMed:11772392) . Colocalized with IGF2R in internalized cytoplasmic vesicles adjacent to the cell surface (PubMed:10900005) . .