Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

CST3

Cystatin-C

CST3 ;
Cystatin-C ;
Cystatin-3 ;
Gamma-trace ;
Neuroendocrine basic polypeptide ;
Post-gamma-globulin

disease:Defects in CST3 are the cause of amyloidosis type 6 (AMYL6) [MIM:105150]; also known as hereditary cerebral hemorrhage with amyloidosis (HCHWA) , cerebral amyloid angiopathy (CAA) or cerebroarterial amyloidosis Icelandic type. AMYL6 is a hereditary generalized amyloidosis due to cystatin C amyloid deposition. Cystatin C amyloid accumulates in the walls of arteries , arterioles , and sometimes capillaries and veins of the brain , and in various organs including lymphoid tissue , spleen , salivary glands , and seminal vesicles. Amyloid deposition in the cerebral vessels results in cerebral amyloid angiopathy , cerebral hemorrage and premature stroke. Cystatin C levels in the cerebrospinal fluid are abnormally low. ,disease:Genetic variations in CST3 are associated with age-related macular degeneration type 11 (ARMD11) [MIM:611953]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients , the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. ,function:As an inhibitor of cysteine proteinases , this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. ,miscellaneous:Potential cerebrospinal fluid marker for the diagnosis of Creutzfeldt-Jakob disease. ,similarity:Belongs to the cystatin family. ,subunit:Homodimer. ,tissue specificity:Found in various body fluids , such as the cerebrospinal fluid and plasma. Expressed in highest levels in the epididymis , vas deferens , brain , thymus , and ovary and the lowest in the submandibular gland. ,

defense response , regulation of catabolic process , negative regulation of catabolic process , negative regulation of peptidase activity , negative regulation of macromolecule metabolic process , regulation of histolysis , negative regulation of histolysis , regulation of collagen catabolic process , negative regulation of collagen catabolic process ,regulation of collagen metabolic process , negative regulation of collagen metabolic process , regulation of extracellular matrix disassembly , negative regulation of extracellular matrix disassembly , extracellular matrix organization ,regulation of cellular catabolic process , negative regulation of cellular catabolic process , regulation of tissue remodeling , negative regulation of tissue remodeling , extracellular structure organization , negative regulation of catalytic activity , fibril organization , negative regulation of molecular function , regulation of multicellular organismal metabolic process , negative regulation of multicellular organismal metabolic process , negative regulation of cellular component organization , negative regulation of multicellular organismal process , regulation of hydrolase activity ,negative regulation of hydrolase activity , regulation of peptidase activity , regulation of elastin catabolic process ,negative regulation of elastin catabolic process , regulation of blood vessel remodeling , negative regulation of blood vessel remodeling ,

Secreted .