Total BCAR3 Cell-Based Colorimetric ELISA Kit
-KA3493C
主要信息
Reactivity
Human
Applications
ELISA
Conjugate/Modification
Unmodified
详细信息
储存
2-8°C/6 months
修饰
Unmodified
检测方法
Colorimetric
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抗原&靶点信息
基因名称:
BCAR3
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别名:
Breast cancer anti-estrogen resistance protein 3 ;
Novel SH2-containing protein 2 ;
SH2 domain-containing protein 3B ;
Novel SH2-containing protein 2 ;
SH2 domain-containing protein 3B ;
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背景:
function:May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins.,PTM:Phosphorylated on tyrosine.,similarity:Contains 1 Ras-GEF domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with BCAR1, NEDD9, PTK2 and PTPN1.,tissue specificity:Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast tissue.,
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功能:
intracellular signaling cascade, small GTPase mediated signal transduction, response to drug,
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细胞定位:
Cytoplasm . Cell junction, focal adhesion . Localization to focal adhesions depends on interaction with PTPRA. .
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组织表达:
Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast tissue.
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