disease:A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7) [MIM:611960]. Asthma-related traits include clinical symptoms of asthma , such as coughing , wheezing and dyspnea , bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test , serum IgE levels , atopy , and atopic dermatitis. ,function:Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens , or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment. ,PTM:Glycosylated. ,similarity:Belongs to the glycosyl hydrolase 18 family. ,subunit:Monomer. ,tissue specificity:Present in activated macrophages , articular chondrocytes , synovial cells as well as in liver. Undetectable in muscle tissues , lung , pancreas , mononuclear cells , or fibroblasts. ,
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