MED24

Mediator of RNA polymerase II transcription subunit 24 ;
Activator-recruited cofactor 100 kDa component ;
ARC100 ;
Cofactor required for Sp1 transcriptional activation subunit 4 ;
CRSP complex subunit 4 ;
Mediator complex subunit 24 ;
Thyroid hormone receptor-associated protein 4 ;
Thyroid hormone receptor-associated protein complex 100 kDa component ;
Trap100 ;
hTRAP100 ;
Vitamin D3 receptor-interacting protein complex 100 kDa component ;
DRIP100 ;

function:Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.,similarity:Belongs to the Mediator complex subunit 24 family.,subunit:Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with AR.,tissue specificity:Ubiquitous. Abundant in skeletal muscle, heart and placenta.,

transcription, transcription, DNA-dependent, transcription initiation, regulation of transcription, DNA-dependent,transcription from RNA polymerase II promoter, transcription initiation from RNA polymerase II promoter, protein complex assembly, intracellular signaling cascade, steroid hormone receptor signaling pathway, androgen receptor signaling pathway, intracellular receptor-mediated signaling pathway, RNA biosynthetic process, macromolecular complex subunit organization, regulation of transcription, regulation of RNA metabolic process, macromolecular complex assembly, protein complex biogenesis,

Nucleus .

Ubiquitous. Abundant in skeletal muscle, heart and placenta.