Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

ACE

Angiotensin-converting enzyme

ACE ;
DCP ;
DCP1 ;
Angiotensin-converting enzyme ;
ACE ;
Dipeptidyl carboxypeptidase I ;
Kininase II ;
CD antigen CD143

catalytic activity:Release of a C-terminal dipeptide , oligopeptide-|-Xaa-Yaa , when Xaa is not Pro , and Yaa is neither Asp nor Glu. Thus , conversion of angiotensin I to angiotensin II , with increase in vasoconstrictor activity , but no action on angiotensin II. ,cofactor:Binds 2 zinc ions per subunit. The Testis-specific isoform only binds 1 zinc ion per subunit. ,cofactor:Binds 3 chloride ions per subunit. ,disease:Defects in ACE are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death , probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype) . ,disease:Genetic variations in ACE could influence susceptibility to diabetic nephropathy [MIM:612624]; also called susceptibility to microvascular complications of diabetes type 3 (MVCD3) or susceptibility to diabetic end-stage renal disease (ESRD) . Diabetic nephropathy is a kidney disease and resultant kidney function impairment due to the long standing effects of diabetes on the microvasculature (glomerulus) of the kidney. Features include increased urine protein and declining kidney function. ,disease:Genetic variations in ACE may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor , sensory and/or cognitive function. Ischemic strokes , resulting from vascular occlusion , is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. ,enzyme regulation:Strongly activated by chloride. Specifically inhibited by lisinopril , captopril and enalaprilat. ,function:Converts angiotensin I to angiotensin II by release of the terminal His-Leu , this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin , a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. ,induction:Up-regulated in failing heart. ,miscellaneous:Inhibitors of ACE are commonly used to treat hypertension and some types of renal and cardiac dysfunction. ,miscellaneous:The glycosidase activity probably uses different active site residues than the metalloprotease activity. ,online information:The Singapore human mutation and polymorphism database ,PTM:Phosphorylated by CK2 on Ser-1299; which allows membrane retention. ,similarity:Belongs to the peptidase M2 family. ,tissue specificity:Ubiquitously expressed , with highest levels in lung , kidney , heart , gastrointestinal system and prostate. The testis-specific isoforn is expressed in spermatocytes , adult testis. ,

blood vessel development , urogenital system development , response to hypoxia , kidney development , vasculature development , blood vessel remodeling , regulation of systemic arterial blood pressure by hormone , regulation of systemic arterial blood pressure by circulatory renin-angiotensin , regulation of angiotensin levels in blood , angiotensin catabolic process in blood , regulation of blood volume by renin-angiotensin , regulation of renal output by angiotensin ,immune system development , circulatory system process , regulation of systemic arterial blood pressure mediated by a chemical signal , regulation of systemic arterial blood pressure , regulation of systemic arterial blood pressure by renin-angiotensin , proteolysis , peptide metabolic process , lipid transport , digestion , blood circulation , regulation of blood pressure , cell proliferation , macromolecule catabolic process , regulation of hormone levels , lipid localization , regulation of smooth muscle cell migration , monocarboxylic acid transport , organic acid transport , fatty acid transport , long-chain fatty acid transport , regulation of vasoconstriction , hemopoiesis , protein catabolic process , regulation of cell migration ,icosanoid secretion , mononuclear cell proliferation , regulation of locomotion , regulation of vasodilation , hormone metabolic process , hormone catabolic process , peptide catabolic process , regulation of system process , multicellular organismal metabolic process , multicellular organismal catabolic process , multicellular organismal protein catabolic process , protein digestion , multicellular organismal macromolecule metabolic process , multicellular organismal macromolecule catabolic process , multicellular organismal protein metabolic process , acid secretion , secretion ,carboxylic acid transport , blood vessel morphogenesis , hemopoietic or lymphoid organ development , tissue remodeling , stem cell differentiation , arachidonic acid secretion , endocrine process , regulation of cell motion ,regulation of angiotensin metabolic process , hemopoietic stem cell differentiation , response to oxygen levels ,leukocyte proliferation ,

[Angiotensin-converting enzyme , soluble form]: Secreted.; Cell membrane; Single-pass type I membrane protein. Cytoplasm . Detected in both cell membrane and cytoplasm in neurons. .