MAP3K13

Mitogen-activated protein kinase kinase kinase 13 ;
Leucine zipper-bearing kinase ;
Mixed lineage kinase ;
MLK ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by autophosphorylation and homodimerization.,function:Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.,PTM:Autophosphorylated on serine and threonine residues.,sequence caution:Translated as Tyr.,sequence caution:Wrong choice of CDS.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Homodimer; forms dimers through the leucine-zipper motif. Interacts with the C-terminus of MAPK8IP1 through the kinase catalytic domain. Binds PRDX3. Associates with the IKK complex through the kinase domain.,tissue specificity:Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas.,

MAPKKK cascade, activation of MAPKK activity, protein amino acid phosphorylation, phosphorus metabolic process,phosphate metabolic process, intracellular signaling cascade, protein kinase cascade, JNK cascade, phosphorylation,regulation of phosphate metabolic process, stress-activated protein kinase signaling pathway, activation of protein kinase activity, cellular response to stress, positive regulation of kinase activity, regulation of phosphorylation,positive regulation of catalytic activity, positive regulation of DNA binding, regulation of kinase activity, positive regulation of molecular function, regulation of transcription, regulation of protein kinase activity, positive regulation of protein kinase activity, protein amino acid autophosphorylation, regulation of transcription factor activity, positive regulation of transcription factor activity, positive regulation of NF-kappaB transcription factor activity, regulation of binding, positive regulation of binding, regulation of DNA binding, regulation of phosphorus metabolic process,regulation of transferase activity, positive regulation of transferase activity,

Cytoplasm . Membrane ; Peripheral membrane protein .

Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas.