KLF11

Krueppel-like factor 11 ;
Transforming growth factor-beta-inducible early growth response protein 2 ;
TGFB-inducible early growth response protein 2 ;
TIEG-2 ;

caution:PubMed:11087666 sequence was originally thought to originate from mouse.,disease:Defects in KLF11 are the cause of maturity-onset diabetes of the young type 7 (MODY7) [MIM:610508]. MODY [MIM:606391] has an autosomal dominant inheritance, onset at age less than 25 years and a primary defect in insulin secretion. MODY pedigrees are usually multigenerational families with penetrance of 80 to 95%. Patients have a nonobese body habitus and the so-called metabolic syndrome characterized by diabetes, insulin resistance, hypertension, and hypertriglyceridemia is absent.,function:Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.,induction:By TGF-beta.,similarity:Belongs to the Sp1 C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,tissue specificity:Ubiquitous. Higher expression in erythroid cells.,

negative regulation of transcription from RNA polymerase II promoter, transcription, transcription, DNA-dependent,regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter, apoptosis, cell death, negative regulation of cell proliferation, negative regulation of biosynthetic process, negative regulation of macromolecule biosynthetic process, negative regulation of macromolecule metabolic process, negative regulation of gene expression, programmed cell death, death, negative regulation of transcription, negative regulation of cellular biosynthetic process, RNA biosynthetic process, regulation of cell proliferation, regulation of transcription, negative regulation of transcription, DNA-dependent, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, negative regulation of nitrogen compound metabolic process, regulation of RNA metabolic process, negative regulation of RNA metabolic process,

Nucleus .

Ubiquitous. Higher expression in erythroid cells.