Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

FLT4 VEGFR3

Vascular endothelial growth factor receptor 3

FLT4 ;
VEGFR3 ;
Vascular endothelial growth factor receptor 3 ;
VEGFR-3 ;
Fms-like tyrosine kinase 4 ;
FLT-4 ;
Tyrosine-protein kinase receptor FLT4

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,disease:Defects in FLT4 are found in juvenile hemangioma. Juvenile hemangiomas are the most common tumors of infancy , occurring as many as 10% of all births. These benign vascular lesions enlarge rapidly during the first year of life by hyperplasia of endothelial cells and attendant pericytes , and then spontaneously involute over a period of years , leaving loose fibrofatty tissue. ,disease:Defects in FLT4 are the cause of lymphedema hereditary type 1 (LYH1A) [MIM:153100]; also known as Nonne-Milroy lymphedema or Milroy disease. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment. ,function:Receptor for VEGFC. Has a tyrosine-protein kinase activity. ,online information:FLT4 entry ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 7 Ig-like C2-type (immunoglobulin-like) domains. ,tissue specificity:Placenta , lung , heart , and kidney , does not seem to be expressed in pancreas and brain. ,

protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein tyrosine kinase signaling pathway , positive regulation of cell proliferation , phosphorylation , regulation of cell proliferation , vascular endothelial growth factor receptor signaling pathway ,

Cell membrane ; Single-pass type I membrane protein. Cytoplasm . Nucleus . Ligand-mediated autophosphorylation leads to rapid internalization. .; [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Ligand-mediated autophosphorylation leads to rapid internalization.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted. Cytoplasm.