Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

CCL15 MIP5 NCC3 SCYA15

C-C motif chemokine 15

MIP-1 delta ;
CCL15 ;
MIP5 ;
NCC3 ;
SCYA15 ;
C-C motif chemokine 15 ;
Chemokine CC-2 ;
HCC-2 ;
Leukotactin-1 ;
LKN-1 ;
Macrophage inflammatory protein 5 ;
MIP-5 ;
Mrp-2b ;
NCC-3 ;
Small-inducible cytokine A15 ;
[Cleaved into: CCL15 ;
22-92 ;
CCL15 ;
25-92 ;
CCL15 ;
29-92 ;
]

function:Chemotactic factor that attracts T-cells and monocytes , but not neutrophils , eosinophils , or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15 (22-92) , CCL15 (25-92) and CCL15 (29-92) are more potent chemoattractants than the small-inducible cytokine A15. ,function:Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca (2+) changes and enzyme release , but no chemotaxis , at concentrations of 100-1 ,000 nM , and was inactive on T-lymphocytes , neutrophils , and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1 (9-74) is a chemotactic factor that attracts monocytes eosinophils , and T-cells and is a ligand for CCR1 , CCR3 and CCR5. ,online information:CCL14 entry ,online information:CCL15 entry ,PTM:HCC-1 (1-74) , but not HCC-1 (3-74) and HCC-1 (4-74) , is partially O-glycosylated; the O-linked glycan consists of one Gal-GalNAc disaccharide , further modified by two N-acetylneuraminic acids. ,PTM:The N-terminal processed forms HCC-1 (3-74) , HCC-1 (4-74) and HCC-1 (9-74) are produced in small amounts by proteolytic cleavage after secretion in blood. ,similarity:Belongs to the intercrine beta (chemokine CC) family. ,subunit:Monomer. ,tissue specificity:Expressed constitutively in several normal tissues: spleen , liver , skeletal and heart muscle , gut , and bone marrow , present at high concentrations (1-80 nM) in plasma. ,tissue specificity:Most abundant in heart , skeletal muscle and adrenal gland. Lower levels in placenta , liver , pancreas and bone marrow. CCL15 (22-92) , CCL15 (25-92) and CCL15 (29-92) are found in high levels in synovial fluids from rheumatoid patients. ,

cellular ion homeostasis , cellular calcium ion homeostasis , cellular metal ion homeostasis , chemotaxis , immune response , cell-cell signaling , behavior , locomotory behavior , positive regulation of cell proliferation , cellular homeostasis , cellular cation homeostasis , cellular di- , tri-valent inorganic cation homeostasis , regulation of cell proliferation , taxis , homeostatic process , chemical homeostasis , ion homeostasis , metal ion homeostasis , di- , tri-valent inorganic cation homeostasis , calcium ion homeostasis , cation homeostasis , cellular chemical homeostasis ,

Secreted.