TNFRSF10A

Tumor necrosis factor receptor superfamily member 10A ;
Death receptor 4 ;
TNF-related apoptosis-inducing ligand receptor 1 ;
TRAIL receptor 1 ;
TRAIL-R1 ;
CD antigen CD261 ;

function:Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.,similarity:Contains 1 death domain.,similarity:Contains 3 TNFR-Cys repeats.,subunit:Can interact with TRADD and RIP. Interacts with ARAP1.,tissue specificity:Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells.,

apoptosis, induction of apoptosis, activation of caspase activity, intracellular signaling cascade, protein kinase cascade, I-kappaB kinase/NF-kappaB cascade, activation of NF-kappaB-inducing kinase activity, cell death, induction of apoptosis by extracellular signals, regulation of cell death, positive regulation of cell death, positive regulation of peptidase activity, programmed cell death, induction of programmed cell death, death, regulation of phosphate metabolic process, activation of protein kinase activity, positive regulation of kinase activity, regulation of phosphorylation, regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death,positive regulation of programmed cell death, positive regulation of catalytic activity, positive regulation of caspase activity, regulation of caspase activity, regulation of kinase activity, positive regulation of molecular function, regulation of protein kinase activity, positive regulation of protein kinase activity, regulation of phosphorus metabolic process,regulation of hydrolase activity, regulation of transferase activity, positive regulation of hydrolase activity, positive regulation of transferase activity, regulation of peptidase activity, regulation of endopeptidase activity,

Cell membrane ; Single-pass type I membrane protein . Membrane raft . Cytoplasm, cytosol . Palmitoylation is required for association with membranes. .

Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.