JMY

Junction-mediating and -regulatory protein

function:Cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage.,induction:By E2F.,PTM:Ubiquitinated by MDM2, leading to its subsequent degradation by the proteasome. In case of DNA damage, the interaction with MDM2 is altered, preventing degradation and allowing interaction with p300/EP300 and its function in p53/TP53 stress response.,similarity:Contains 1 WH2 domain.,subunit:Interacts with p300/EP300, the complex being recruited to activated p53/TP53. Interacts with TTC5.,

DNA metabolic process, DNA repair, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, induction of apoptosis, response to DNA damage stimulus, cell cycle, cell cycle arrest,regulation of cell death, positive regulation of cell death, induction of programmed cell death, cell cycle process, cellular response to stress, regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death,positive regulation of programmed cell death, positive regulation of DNA binding, positive regulation of molecular function, regulation of transcription, regulation of transcription factor activity, positive regulation of transcription factor activity, regulation of binding, positive regulation of binding, regulation of DNA binding, regulation of RNA metabolic process,

Nucleus . Cytoplasmic vesicle . Cytoplasm, cytoskeleton . Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane . Localizes to the nucleus in most cell types. Accumulates in nucleus under DNA damage conditions, increasing p53/TP53 transcription response and reducing its influence on cell motility (By similarity). In primary neutrophils, it colocalizes with actin filaments at the leading edge and is excluded from the nucleus. Localization correlates with motility, because it moves from the nucleus to the cytoplasmic compartment when cells are differentiated from nonmotile cells into highly motile neutrophil-like cells. Localizes to cytoplasmic vesicles which associate with actin filament and autophagosomal membranes upon starvation-induced autophagy (PubMed:30420355). .