UBA7

Ubiquitin-like modifier-activating enzyme 7 ;
Ubiquitin-activating enzyme 7 ;
D8 ;
Ubiquitin-activating enzyme E1 homolog ;

function:Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP.,miscellaneous:There are two active sites within the E1 molecule, allowing it to accommodate two ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-activating E1 family.,subunit:Monomer (By similarity). Binds and is involved in the conjugation of G1P2/ISG15.,tissue specificity:Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines.,

proteolysis, macromolecule catabolic process, modification-dependent protein catabolic process, protein catabolic process, ISG15-protein conjugation, modification-dependent macromolecule catabolic process, cellular protein catabolic process, cellular macromolecule catabolic process, proteolysis involved in cellular protein catabolic process,

Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines.