SENP2

Sentrin-specific protease 2 ;
Axam2 ;
SMT3-specific isopeptidase 2 ;
Smt3ip2 ;
Sentrin/SUMO-specific protease SENP2 ;

domain:The N-terminus is necessary and sufficient for nuclear envelope targeting.,function:Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway.,PTM:Polyubiquitinated; which leads to proteasomal degradation.,similarity:Belongs to the peptidase C48 family.,subcellular location:Shuttles between cytoplasm and nucleus.,subunit:Binds to SUMO2 and SUMO3 (By similarity). Interacts with the C-terminal domain of NUP153 via its N-terminus.,

RNA localization, proteolysis, cell surface receptor linked signal transduction, protein localization, macromolecule catabolic process, protein transport, nucleobase, nucleoside, nucleotide and nucleic acid transport, Wnt receptor signaling pathway, protein desumoylation, modification-dependent protein catabolic process, regulation of Wnt receptor signaling pathway, protein catabolic process, modification-dependent macromolecule catabolic process,cellular protein catabolic process, cellular macromolecule catabolic process, establishment of protein localization,nucleic acid transport, RNA transport, mRNA transport, establishment of RNA localization, proteolysis involved in cellular protein catabolic process, transmembrane transport, protein modification by small protein removal, protein modification by small protein conjugation or removal,

Nucleus, nuclear pore complex . Nucleus membrane ; Peripheral membrane protein ; Nucleoplasmic side . Cytoplasm . Shuttles between cytoplasm and nucleus. .