Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

CSF3R

Granulocyte colony-stimulating factor receptor

CSF3R ;
GCSFR ;
Granulocyte colony-stimulating factor receptor ;
G-CSF receptor ;
G-CSF-R ;
CD antigen CD114

alternative products:Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms ,disease:Defects in CSF3R may be a cause of severe congenital neutropenia (SCN) in some patients. ,domain:The box 1 motif is required for JAK interaction and/or activation. ,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. ,function:Receptor for granulocyte colony-stimulating factor (CSF3) . In addition it may function in some adhesion or recognition events at the cell surface. ,similarity:Belongs to the type I cytokine receptor family. Type 2 subfamily. ,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain. ,similarity:Contains 5 fibronectin type-III domains. ,subunit:Homodimer. The dimeric receptor binds two CSF3 molecules. ,tissue specificity:One or several isoforms have been found in myelogenous leukemia cell line KG-1 , leukemia U937 cell line , in bone marrow cells , placenta , and peripheral blood granulocytes. Isoform GCSFR-2 is found only in leukemia U937 cells. Isoform GSCFR-3 is highly expressed in placenta. ,

defense response , cell adhesion , biological adhesion ,

[Isoform 2]: Secreted .; Cell membrane ; Single-pass type I membrane protein .