Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

FASLG

Tumor necrosis factor ligand superfamily member 6

FASLG ;
APT1LG1 ;
CD95L ;
FASL ;
TNFSF6 ;
Tumor necrosis factor ligand superfamily member 6 ;
Apoptosis antigen ligand ;
APTL ;
CD95 ligand ;
CD95-L ;
Fas antigen ligand ;
Fas ligand ;
FasL ;
CD antigen CD178

disease:Defects in FASLG are the cause of autoimmune lymphoproliferative syndrome type 1B (ALPS1B) [MIM:601859]; also known as Canale-Smith syndrome (CSS) . ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly. ,function:Cytokine that binds to TNFRSF6/FAS , a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance , in the antigen-stimulated suicide of mature T-cells , or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. ,online information:FAS-ligand entry ,online information:FASLG mutation db ,PTM:N-glycosylated. ,PTM:The soluble form derives from the membrane form by proteolytic processing. ,similarity:Belongs to the tumor necrosis factor family. ,subcellular location:May be released into the extracellular fluid , probably by cleavage form the cell surface. ,subunit:Homotrimer. ,

eye development , response to molecule of bacterial origin , apoptosis , induction of apoptosis , inflammatory cell apoptosis , immune response , cell-cell signaling , sensory organ development , cell death , induction of apoptosis by extracellular signals , activation of pro-apoptotic gene products , response to bacterium , positive regulation of signal transduction , response to organic substance , developmental programmed cell death , regulation of protein kinase cascade , positive regulation of cell communication , positive regulation of protein kinase cascade , regulation of necrotic cell death , positive regulation of necrotic cell death , regulation of cell death , positive regulation of cell death ,programmed cell death , induction of programmed cell death , death , response to lipopolysaccharide , regulation of apoptosis , positive regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , regulation of I-kappaB kinase/NF-kappaB cascade , positive regulation of I-kappaB kinase/NF-kappaB cascade , retinal cell programmed cell death , eye morphogenesis , regulation of necroptosis , positive regulation of necroptosis , induction of necroptosis , induction of necroptosis of activated-T cells , induction of necroptosis by extracellular signals , necrotic cell death ,

Cell membrane ; Single-pass type II membrane protein . Cytoplasmic vesicle lumen . Lysosome lumen . Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination (PubMed:17164290) . Colocalizes with the SPPL2A protease at the cell membrane (PubMed:17557115) . .; [Tumor necrosis factor ligand superfamily member 6 , soluble form]: Secreted . May be released into the extracellular fluid by cleavage from the cell surface. .; [FasL intracellular domain]: Nucleus . The FasL ICD cytoplasmic form is translocated into the nucleus. .