Total NUB1 Cell-Based Colorimetric ELISA Kit
-KA3409C
主要信息
Reactivity
Human, Mouse
Applications
ELISA
Conjugate/Modification
Unmodified
详细信息
储存
2-8°C/6 months
修饰
Unmodified
检测方法
Colorimetric
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抗原&靶点信息
基因名称:
NUB1
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别名:
NEDD8 ultimate buster 1 ;
Negative regulator of ubiquitin-like proteins 1 ;
Renal carcinoma antigen NY-REN-18 ;
Negative regulator of ubiquitin-like proteins 1 ;
Renal carcinoma antigen NY-REN-18 ;
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背景:
function:Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8 and its conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.,induction:By beta and gamma interferons.,similarity:Contains 3 UBA domains.,subcellular location:Predominantly nuclear.,subunit:Directly interacts with NEDD8 and PSMD4/S5a, a member of the regulatory subunit of the 26S proteasome. Isoform 1 binds to NEDD8 more efficiently than isoform 2. Interacts with AIPL1.,tissue specificity:Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver, prostate and skeletal muscle for isoform 2.,
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细胞定位:
Nucleus . Predominantly nuclear.
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组织表达:
Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver, prostate and skeletal muscle for isoform 2.
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