NEDD8

NEDD8 ;
Neddylin ;
Neural precursor cell expressed developmentally down-regulated protein 8 ;
NEDD-8 ;
Ubiquitin-like protein Nedd8 ;

function:Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.,PTM:Cleavage of precursor form by UCHL3 or SENP8 is necessary for function.,similarity:Belongs to the ubiquitin family.,subcellular location:Mainly nuclear.,subunit:Directly interacts with NUB1 and AHR. Covalently attached to cullins and p53.,tissue specificity:Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes.,

regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, proteolysis,ubiquitin-dependent protein catabolic process, protein localization, macromolecule catabolic process, response to organic substance, response to organic cyclic substance, modification-dependent protein catabolic process, protein catabolic process, protein modification by small protein conjugation, modification-dependent macromolecule catabolic process, cellular protein catabolic process, cellular macromolecule catabolic process, protein neddylation, regulation of transcription, regulation of RNA metabolic process, proteolysis involved in cellular protein catabolic process, protein modification by small protein conjugation or removal,

Nucleus . Mainly nuclear. .

Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes.