NCOR1

Nuclear receptor corepressor 1 ;
N-CoR ;
N-CoR1 ;

domain:The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity.,domain:The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3).,function:Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors.,PTM:Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the N-CoR nuclear receptor corepressors family.,similarity:Contains 2 SANT domains.,subunit:Interacts with SIAH2, HDAC7, SAP30, SIN3A and SIN3B (By similarity). Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand. Interacts with DACH1. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Interacts with TRIM28 and MJD2A/JHDM3A. Interacts with ZBTB33/KAISO, and this interaction serves to recruit the N-CoR complex to promoter regions containing methylated CpG dinucleotides. Interacts with the catalytic domain of HDAC9. Interacts with CBFA2T3 and HEXIM1. Interacts with C1D.,

negative regulation of transcription from RNA polymerase II promoter, microtubule cytoskeleton organization, M phase, chromatin organization, transcription, transcription, DNA-dependent, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter, cytoskeleton organization, microtubule-based process, cell cycle, spindle organization, negative regulation of biosynthetic process, negative regulation of signal transduction, regulation of specific transcription from RNA polymerase II promoter, negative regulation of specific transcription from RNA polymerase II promoter, negative regulation of macromolecule biosynthetic process, negative regulation of macromolecule metabolic process, regulation of protein kinase cascade, negative regulation of gene expression, negative regulation of cell communication, negative regulation of protein kinase cascade, negative regulation of transcription, chromatin modification, cell cycle process,cell cycle phase, negative regulation of cellular biosynthetic process, negative regulation of gene-specific transcription,regulation of gene-specific transcription, RNA biosynthetic process, regulation of MAPKKK cascade, negative regulation of MAPKKK cascade, regulation of transcription, negative regulation of transcription, DNA-dependent, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, regulation of JNK cascade,negative regulation of JNK cascade, negative regulation of response to stimulus, negative regulation of nitrogen compound metabolic process, spindle assembly, regulation of RNA metabolic process, negative regulation of RNA metabolic process, chromosome organization, regulation of stress-activated protein kinase signaling pathway,negative regulation of stress-activated protein kinase signaling pathway, regulation of cellular response to stress,

Nucleus .