TGM2

Protein-glutamine gamma-glutamyltransferase 2 ;
Tissue transglutaminase ;
Transglutaminase C ;
TG ;
C ;
TGC ;
TGase C ;
Transglutaminase H ;
TGase H ;
Transglutaminase-2 ;
TGase-2 ;

catalytic activity:Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).,cofactor:Binds 1 calcium ion per subunit.,disease:Defects in TGM2 are involved in early-onset diabetes type 2.,function:Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.,induction:By retinoic acid.,online information:Tissue transglutaminase entry,similarity:Belongs to the transglutaminase superfamily. Transglutaminase family.,subunit:Monomer.,

blood vessel development, vasculature development, blood vessel remodeling, protein complex assembly, cellular ion homeostasis, cellular calcium ion homeostasis, cellular metal ion homeostasis, anti-apoptosis, induction of apoptosis,cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway, activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger,activation of phospholipase C activity, elevation of cytosolic calcium ion concentration, intracellular signaling cascade,cell death, positive regulation of cell proliferation, positive regulation of signal transduction, regulation of phospholipase activity, positive regulation of phospholipase activity, regulation of protein kinase cascade, positive regulation of cell communication, positive regulation of protein kinase cascade, positive regulation of phospholipase C activity, regulation of cell death, positive regulation of cell death, programmed cell death, induction of programmed cell death, death, peptide cross-linking, isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine, peptidyl-glutamine modification, peptidyl-lysine modification, isopeptide cross-linking, cytokine-mediated signaling pathway, cellular homeostasis, second-messenger-mediated signaling, cAMP-mediated signaling, cyclic-nucleotide-mediated signaling,cellular cation homeostasis, cellular di-, tri-valent inorganic cation homeostasis, regulation of cell adhesion, positive regulation of defense response, regulation of response to external stimulus, positive regulation of response to external stimulus, regulation of cell proliferation, homeostatic process, regulation of apoptosis, positive regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, negative regulation of programmed cell death, positive regulation of catalytic activity, regulation of I-kappaB kinase/NF-kappaB cascade, positive regulation of I-kappaB kinase/NF-kappaB cascade, macromolecular complex subunit organization, positive regulation of molecular function, positive regulation of cell adhesion,phosphoinositide-mediated signaling, blood vessel morphogenesis, positive regulation of response to stimulus,regulation of smooth muscle cell proliferation, positive regulation of smooth muscle cell proliferation, tissue remodeling, chemical homeostasis, regulation of inflammatory response, positive regulation of inflammatory response,ion homeostasis, protein oligomerization, protein homooligomerization, regulation of hydrolase activity, positive regulation of hydrolase activity, cytosolic calcium ion homeostasis, elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating), metal ion homeostasis, di-, tri-valent inorganic cation homeostasis, calcium ion homeostasis, cation homeostasis, cellular chemical homeostasis,regulation of lipase activity, positive regulation of lipase activity, negative regulation of cell death, macromolecular complex assembly, protein complex biogenesis,

Cytoplasm, cytosol . Nucleus . Chromosome . Secreted, extracellular space, extracellular matrix . Cell membrane . Mitochondrion . Mainly localizes to the cytosol (PubMed:9575137). Present at much lower level in the nucleus and chromatin (PubMed:9575137). Also secreted via a non-classical secretion pathway to the extracellular matrix (PubMed:27270573). .; [Isoform 2]: Cytoplasm, perinuclear region .