SKP2

S-phase kinase-associated protein 2 ;
Cyclin-A/CDK2-associated protein p45 ;
F-box protein Skp2 ;
F-box/LRR-repeat protein 1 ;
p45skp2 ;

function:Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1L, CDT1, RBL2, MLL, CDK9, RAG2, FOXO1A, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 F-box domain.,similarity:Contains 8 LRR (leucine-rich) repeats.,subunit:Part of the SCF(SKP2) complex consisting of CUL1, RBX1, SKP1 and SKP2. Interacts directly with CUL1 and SKP1. Interacts with CKS1. Interacts with the cyclin A-CDK2 complex. Interacts with ORC1L, phosphorylated CDT1, phosphorylated RBL2, ELF4, phosphorylated RAG2, FOXO1A, UBP43, MYC, TOB1, TAL1 and MLL.,

G1/S transition of mitotic cell cycle, mitotic cell cycle, proteolysis, ubiquitin-dependent protein catabolic process, anti-apoptosis, cell cycle, cell proliferation, negative regulation of survival gene product expression, macromolecule catabolic process, negative regulation of macromolecule metabolic process, negative regulation of gene expression,regulation of cell death, positive regulation of cell death, modification-dependent protein catabolic process, cell cycle process, cell cycle phase, protein catabolic process, regulation of apoptosis, positive regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, negative regulation of programmed cell death, modification-dependent macromolecule catabolic process, cellular protein catabolic process, cellular macromolecule catabolic process, regulation of survival gene product expression,interphase, interphase of mitotic cell cycle, proteolysis involved in cellular protein catabolic process, regulation of cell cycle, negative regulation of cell death,

Cytoplasm . Nucleus .