SKP1

S-phase kinase-associated protein 1 ;
Cyclin-A/CDK2-associated protein p19 ;
Organ of Corti protein 2 ;
OCP-2 ;
Organ of Corti protein II ;
OCP-II ;
RNA polymerase II elongation factor-like protein ;
SIII ;
Transcription elongation factor B ;
p19A ;
p19skp1 ;

function:Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the SKP1 family.,subunit:Interacts directly with CUL1 and F-box proteins, such as BTRC and SKP2, in the SCF complex. Interacts with the cyclin A/CDK2 complex. Part of a SCF-like complex consisting of CUL7, RBX1, SKP1 and FBXW8. Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X.,

mitotic cell cycle, proteolysis, ubiquitin-dependent protein catabolic process, cell cycle, macromolecule catabolic process, positive regulation of macromolecule metabolic process, modification-dependent protein catabolic process,cell cycle process, protein catabolic process, regulation of protein ubiquitination, positive regulation of protein ubiquitination, regulation of protein modification process, positive regulation of protein modification process,regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, positive regulation of catalytic activity, modification-dependent macromolecule catabolic process, positive regulation of molecular function, cellular protein catabolic process, cellular macromolecule catabolic process, positive regulation of protein metabolic process, regulation of ligase activity, positive regulation of ligase activity, positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle, regulation of ubiquitin-protein ligase activity, regulation of ubiquitin-protein ligase activity during mitotic cell cycle, positive regulation of ubiquitin-protein ligase activity,proteolysis involved in cellular protein catabolic process,