Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

TIMP1

Metalloproteinase inhibitor 1

TIMP1 ;
CLGI ;
TIMP ;
Metalloproteinase inhibitor 1 ;
Erythroid-potentiating activity ;
EPA ;
Fibroblast collagenase inhibitor ;
Collagenase inhibitor ;
Tissue inhibitor of metalloproteinases 1 ;
TIMP-1

function:Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Also mediates erythropoiesis in vitro; but , unlike IL-3 , it is species-specific , stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1 , MMP-2 , MMP-3 , MMP-7 , MMP-8 , MMP-9 , MMP-10 , MMP-11 , MMP-12 , MMP-13 and MMP-16. Does not act on MMP-14. ,PTM:The activity of TIMP1 is dependent on the presence of disulfide bonds. ,similarity:Belongs to the protease inhibitor I35 (TIMP) family. ,similarity:Contains 1 NTR domain. ,

immune system development , positive regulation of cell proliferation , regulation of catabolic process , negative regulation of catabolic process , negative regulation of macromolecule metabolic process , developmental maturation ,hemopoiesis , myeloid cell differentiation , regulation of proteolysis , erythrocyte differentiation , regulation of cellular catabolic process , negative regulation of cellular catabolic process , regulation of cellular protein metabolic process ,negative regulation of cellular protein metabolic process , erythrocyte homeostasis , regulation of cell proliferation ,regulation of protein catabolic process , negative regulation of protein catabolic process , homeostatic process ,erythrocyte maturation , negative regulation of proteolysis , cell maturation , hemopoietic or lymphoid organ development , erythrocyte development , homeostasis of number of cells , regulation of membrane protein ectodomain proteolysis , negative regulation of membrane protein ectodomain proteolysis , negative regulation of protein metabolic process ,

Secreted .