Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

SERPINE1

Plasminogen activator inhibitor 1

SERPINE1 ;
PAI1 ;
PLANH1 ;
Plasminogen activator inhibitor 1 ;
PAI ;
PAI-1 ;
Endothelial plasminogen activator inhibitor ;
Serpin E1

disease:Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency) [MIM:173360]. This deficiency is characterized by abnormal bleeding due to SERPINE1 defect in the plasma. ,disease:High concentrations of SERPINE1 have been associated with thrombophilia [MIM:188050]; an autosomal dominant disorder in which affected individuals are prone to develop serious spontaneous thrombosis. ,function:This inhibitor acts as 'bait' for tissue plasminogen activator , urokinase , and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. ,online information:Plasminogen activator inhibitor-1 entry ,PTM:Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA) , cleaving the 369-Arg-|-Met-370 bond. ,similarity:Belongs to the serpin family. ,subunit:Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation. ,tissue specificity:Found in plasma and platelets and in endothelial , hepatoma and fibrosarcoma cells. ,

response to reactive oxygen species , chronological cell aging , response to oxidative stress , aging , cell aging , blood coagulation , hemostasis , response to wounding , response to inorganic substance , regulation of blood coagulation ,negative regulation of blood coagulation , regeneration , regulation of response to external stimulus , carbohydrate homeostasis , growth , wound healing , regulation of cell proliferation , tissue regeneration , homeostatic process ,glucose homeostasis , fibrinolysis , regulation of angiogenesis , developmental growth , chemical homeostasis ,coagulation , regulation of coagulation , negative regulation of coagulation , regulation of body fluid levels , negative regulation of multicellular organismal process ,

Secreted .