Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

MIA2

Melanoma inhibitory activity protein 2

MIA2 ;
Melanoma inhibitory activity protein 2

disease:Autoantigen found several cancer types , including benign meningioma and cutaneous T-cell lymphoma (CTCL) . Isoform 5A and isoform 5B are recognized by patients' sera with tumor specimen of various origins. ,disease:Tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL) . Also found in colorectal and breast carcinomas , head and neck squamous cell carcinomas and melanoma. ,function:Tumor-associated antigen. ,sequence caution:Translation N-terminally extended. ,similarity:Belongs to the cTAGE family. ,tissue specificity:At the protein level , isoform 5A is expressed only in testis. Other isoforms are expressed in several other normal tissues , including brain , muscle and cranial skin. Isoform 5A (at the protein level) and isoform 5B are expressed in cutaneous T-cell lymphoma (CTCL) cell lines , colorectal carcinomas , breast carcinomas and melanoma. Isoform 5B , but not isoform 5A , is expressed in head and neck squamous cell carcinoma. ,tissue specificity:Expressed in testis , placenta and skin. Expressed at lower level in mammary gland and stomach. ,

Endoplasmic reticulum membrane ; Single-pass membrane protein . Localizes to endoplasmic reticulum exit sites (ERES) , also known as transitional endoplasmic reticulum (tER) . .