PDGFB

Platelet-derived growth factor subunit B ;
PDGF subunit B ;
PDGF-2 ;
Platelet-derived growth factor B chain ;
Platelet-derived growth factor beta polypeptide ;
Proto-oncogene c-Sis ;
Becaplermin ;

disease:A chromosomal aberration involving PDGFB is a cause of dermatofibrosarcoma protuberans (DFSP) [MIM:607907]. Translocation t(17;22)(q22;q13) with COLA1. DFSP is an uncommon, locally aggressive, but rarely metastasizing tumor of the deep dermis and subcutaneous tissue. It typically occurs during early or middle adult life and is most frequently located on the trunk and proximal extremities.,function:Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.,miscellaneous:A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor.,online information:Clinical information on Regranex,pharmaceutical:Available under the name Regranex (Ortho-McNeil). Used to promote healing in diabetic neuropathic foot ulcers.,similarity:Belongs to the PDGF/VEGF growth factor family.,subunit:Antiparallel disulfide-linked dimer of non-identical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes. Interacts with XLKD1.,tissue specificity:Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.,

response to hypoxia, regulation of protein amino acid phosphorylation, regulation of endothelial cell proliferation,positive regulation of endothelial cell proliferation, monocyte chemotaxis, DNA metabolic process, DNA replication,regulation of DNA replication, cell motion, substrate-bound cell migration, chemotaxis, cytoskeleton organization, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, transmembrane receptor protein serine/threonine kinase signaling pathway, transforming growth factor beta receptor signaling pathway, behavior, locomotory behavior, cell proliferation, positive regulation of cell proliferation, regulation of cell size, response to wounding, response to endogenous stimulus, response to hormone stimulus, negative regulation of biosynthetic process, positive regulation of biosynthetic process, response to organic substance, regulation of phosphatidylinositol biosynthetic process,negative regulation of phosphatidylinositol biosynthetic process, regulation of platelet activation, negative regulation of platelet activation, positive regulation of macromolecule biosynthetic process, regulation of endothelial cell migration, positive regulation of endothelial cell migration, positive regulation of macromolecule metabolic process,regulation of smooth muscle cell migration, positive regulation of smooth muscle cell migration, cell growth, cell migration, regulation of lipid metabolic process, regulation of phosphate metabolic process, actin filament-based process, cell projection organization, cell projection assembly, actin cytoskeleton organization, regulation of blood coagulation, negative regulation of blood coagulation, regulation of cell migration, positive regulation of cell migration,negative regulation of cell migration, leukocyte chemotaxis, negative regulation of cellular biosynthetic process,positive regulation of cellular biosynthetic process, regulation of protein modification process, regulation of response to external stimulus, positive regulation of response to external stimulus, regulation of cellular protein metabolic process, response to estradiol stimulus, regulation of cellular component size, positive regulation of kinase activity,growth, regulation of locomotion, negative regulation of locomotion, positive regulation of locomotion, wound healing,regulation of cell proliferation, regulation of phosphorylation, taxis, positive regulation of catalytic activity, regulation of MAP kinase activity, positive regulation of MAP kinase activity, regulation of blood vessel endothelial cell migration,positive regulation of blood vessel endothelial cell migration, regulation of kinase activity, response to estrogen stimulus, positive regulation of molecular function, positive regulation of DNA replication, negative regulation of lipid metabolic process, regulation of protein kinase activity, positive regulation of protein kinase activity, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, regulation of lipid biosynthetic process, platelet-derived growth factor receptor signaling pathway, regulation of fibroblast proliferation, positive regulation of fibroblast proliferation, positive regulation of behavior, response to steroid hormone stimulus, positive regulation of response to stimulus, regulation of smooth muscle cell proliferation, positive regulation of smooth muscle cell proliferation, cell motility, regulation of peptidyl-tyrosine phosphorylation, regulation of behavior, regulation of coagulation, negative regulation of coagulation, regulation of cell activation, negative regulation of cell activation,leukocyte migration, regulation of chemotaxis, positive regulation of chemotaxis, regulation of DNA metabolic process,positive regulation of DNA metabolic process, negative regulation of lipid biosynthetic process, positive regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process, negative regulation of multicellular organismal process, regulation of cell motion, negative regulation of cell motion, positive regulation of cell motion,regulation of cell division, regulation of transferase activity, positive regulation of transferase activity, localization of cell, positive regulation of cell division, cell chemotaxis, response to oxygen levels,

Secreted. Released by platelets upon wounding.

Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.